FRENNL
Pharmaceutical industry, cleanrooms, Belgium & Luxembourg

Dry ice blasting for the pharmaceutical industry

Production equipment, cleanroom surfaces and pharmaceutical machinery require rigorous cleaning without water, without chemicals and without residue. Dry ice blasting meets the strict requirements of the sector while keeping your production lines running.

Zero residue No cross-contamination Compliant cleanroom process Fast return to production
Why dry ice blasting

A technology suited to pharmaceutical requirements

Zero chemical residue

CO2 is classified E290, an inert food and pharmaceutical-grade additive. No product used, no residue to rinse, no cross-contamination risk between batches.

Compatible with cleanrooms

Dry, particle-free process compatible with controlled environments. No liquid introduced, no risk of condensation on sensitive equipment.

No disassembly

Cleaning in place on installed equipment. No disassembly, no reassembly: saves time and eliminates reassembly error risks.

Full traceability

Detailed intervention report for your quality documentation, essential for pharmaceutical audits and GMP compliance.

Sectors concerned

Who calls on Icetec in the pharmaceutical field?

01

Drug manufacturers

Production sites requiring rigorous cleaning between batches with no cross-contamination.

02

Contract manufacturers (CDMO)

Subcontracting labs needing fast, validated equipment changeover between clients.

03

Research laboratories

R&D and quality control labs with sensitive equipment requiring particle-free cleaning.

04

Medical device manufacturers

Precision cleaning of moulds and equipment used in medical device production.

05

Cosmetics & nutraceuticals

Similar hygiene requirements to pharma, dry ice blasting suits both sectors equally well.

Equipment treated

What we clean in your facility

01

Tablet presses & compression tooling

Removal of powder residue and build-up on punches, dies and compression tooling with no cross-contamination.

02

Mixing & granulation equipment

Cleaning of mixers, granulators and powder handling equipment between formulations.

03

Filling & packaging lines

Cleaning of filling machines, capping equipment and packaging lines with minimal downtime.

04

Reactors & synthesis vessels

Decontamination between batches, removal of residue from complex internal geometries.

05

Cleanroom surfaces & walls

Particle-free cleaning of walls, ceilings and surfaces in classified cleanroom environments.

06

Injection moulds (medical grade)

Precision cleaning of medical-grade moulds preserving surface finish and dimensional accuracy.

Our process

How does an intervention work?

01

Free quote

Describe your equipment and quality constraints. We respond within 6 hours with an accurate estimate.

02

Planning

Intervention scheduled around your production and quality windows for zero impact.

03

Intervention

Our technicians intervene with Cryonomic equipment. Cleaning in place, no disassembly.

04

Quality report

Intervention report provided for your quality file, full traceability for GMP compliance.

Frequently asked questions

Dry ice blasting for pharma

Yes. The process uses food/pharma-grade CO2 (E290), is entirely dry and leaves no residue. It is widely used in pharmaceutical environments subject to GMP because it eliminates the cross-contamination risks associated with chemical cleaning agents.
Yes, with appropriate precautions. The process generates no liquid and minimal particle load compared to manual cleaning with cloths. Icetec assesses the classification level of your room and adapts the intervention protocol accordingly.
Considerably less than traditional chemical cleaning with disassembly. Since the process is dry and requires no drying time, equipment can return to production immediately after the intervention, often reducing downtime by more than half.
Yes. Icetec provides a detailed intervention report including parameters used, equipment treated and observations, suitable for integration into your quality management system and GMP audit files.

Request a free quote

Describe your equipment and quality requirements. An Icetec expert will assess feasibility and get back to you, no obligation.

Scroll to Top